UNC 669
- Product Name
- UNC 669
- CAS No.
- 1314241-44-5
- Chemical Name
- UNC 669
- Synonyms
- UNC699;UNC 669;CS-1146;UNC669, >=98%;UNC 669; UNC-669;UNC 669 USP/EP/BP;UNC669 L3MBTL antagonist UNC-669;(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone;(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone;METHANONE, (5-BROMO-3-PYRIDINYL)[4-(1-PYRROLIDINYL)-1-PIPERIDINYL]-
- CBNumber
- CB92682025
- Molecular Formula
- C15H20BrN3O
- Formula Weight
- 338.24
- MOL File
- 1314241-44-5.mol
UNC 669 Property
- Boiling point:
- 458.0±45.0 °C(Predicted)
- Density
- 1.424±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20° C
- solubility
- insoluble in H2O; ≥52.4 mg/mL in EtOH with ultrasonic; ≥9.35 mg/mL in DMSO
- form
- solid
- pka
- 9.78±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 10875
- Product name
- UNC669
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 10875
- Product name
- UNC669
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 10875
- Product name
- UNC669
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 10875
- Product name
- UNC669
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- B687340
- Product name
- (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
- Packaging
- 50mg
- Price
- $120
- Updated
- 2021/12/16
UNC 669 Chemical Properties,Usage,Production
Uses
(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT).
Definition
ChEBI: (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is an aromatic carboxylic acid and a pyridinemonocarboxylic acid.
Biological Activity
unc 669 is a potent antagonist of l3mbtl1 (ic50=4.2 μm) and l3mbtl3 (ic50=3.1 μm).there is less bio-data supported for unc669. unc1679 is an analog of unc669. unc1215 is the first potent and selective antagonism of a methyl-lysine reader protein, l3mbtl3, which antagonizes the mono- and dimethyl-lysine reading function of l3mbtl3. [1]lysine methylation is a key epigenetic landmark, the dysregulation of which is related to many diseases. unc1679 maintains in vitro and cellular potency with improved selectivity against other mbt-containing proteins. the antagonists described were also found to effectively interact with unlabeled endogenous l3mbtl3 in cells. [1]
target
L3MBTL1
References
1. james li, korboukh vk, krichevsky l et al. small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for l3mbtl3. j med chem. 2013 sep 26;56(18):7358-71. doi: 10.1021/jm400919p. epub 2013 sep 16.
UNC 669 Preparation Products And Raw materials
Raw materials
Preparation Products
UNC 669 Suppliers
View Lastest Price from UNC 669 manufacturers
- Product
- UNC 669 314241-44-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23